Aromatic Amino Acid Hydroxylases and Mental Disease
نویسندگان
چکیده
منابع مشابه
Introducing aromatic amino acid hydroxylases from plants.
In humans, a deficiency in Phe hydroxylase activity results in phenylketonuria, a metabolic disorder that is characterized by the accumulation of Phe. Phe hydroxylase belongs to the iron-containing aromatic amino acid hydroxylase (AAH) family, whose members catalyze the hydroxylation of Phe, Trp, or Tyr in a reaction that depends on the donation of electrons by tetrahydropterin (reviewed in Fit...
متن کاملGlyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence.
Glyceryl ether monooxygenase is a tetrahydrobiopterin-dependent membrane-bound enzyme which catalyses the cleavage of lipid ethers into glycerol and the corresponding aldehyde. Despite many different characterisation and purification attempts, so far no gene and primary sequence have been assigned to this enzyme. The seven other tetrahydrobiopterin-dependent enzymes can be divided in the family...
متن کاملAromatic amino acid hydroxylase genes and schizophrenia.
Phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine, shares physical, structural and catalytic properties with tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) that catalyze the rate-limiting steps in the biosynthesis of the neurotransmitters dopamine, noradrenaline, and serotonin. Because these neurotransmitter systems have all been implicated...
متن کاملShikimate Pathway and Aromatic Amino Acid Biosynthesis
The shikimate pathway consists of seven enzymatic reactions whose end product chorismate is the precursor for the synthesis of the aromatic amino acids Phe, Tyr and Trp. In fungi and plants, chorismate is a precursor for many specialised metabolites (i.e. secondary metabolites) that play an important role in the plant’s interaction with its environment. The shikimate pathway and aromatic amino ...
متن کاملReassessment of the role of aromatic amino acid hydroxylases and the effect of infection by Toxoplasma gondii on host dopamine.
Toxoplasma gondii infection has been described previously to cause infected mice to lose their fear of cat urine. This behavioral manipulation has been proposed to involve alterations of host dopamine pathways due to parasite-encoded aromatic amino acid hydroxylases. Here, we report successful knockout and complementation of the aromatic amino acid hydroxylase AAH2 gene, with no observable phen...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1980
ISSN: 0022-3050
DOI: 10.1136/jnnp.43.11.1052-a